Power BI developers must be adept at working with large datasets because many businesses rely on vast amounts of data from multiple sources. Handling large datasets requires an understanding of data warehousing, optimization techniques, and performance tuning. Power BI developers should be skilled in structuring and querying data to ensure quick load times and smooth report interactions. Managing large datasets also demands strong ETL skills to cleanse and transform data effectively, ensuring that the visualizations are accurate, responsive, and informative, even when dealing with millions of rows of data.