Catalina Garcia CRP Protein

At Creative Biolabs, our pioneering advancements in the field of neurochemistry assays are at the forefront of neuroscience research. With over two decades of expertise in the industry, we have established ourselves as a leading provider of cutting-edge technology platforms and comprehensive assay solutions for neurochemistry research.

As a global-leading CRO company, Creative Biolabs has a great reputation for providing neuroscience-based services. We have optimized our neuroscience in vitro model platform with advanced technologies, high-quality facilities, and professional experts. Our platform can offer reliable custom CNS disease modeling services including but not limited to Alzheimer's disease models, Huntington's disease models, and Parkinson's disease models. All these advantages consist of strong guarantees of the quality of our services.

CD28 is one of the most important costimulatory molecules expressed by naive and primed T cells and is essential for full T cell activation and the development and homeostasis of Treg cells. CD80 (B7-1) and CD86 (B7-2) represent the two structurally homologous ligands of CD28, which are expressed by antigen-presenting cells (APCs), including dendritic cells (DCs). Expression of each ligand is upregulated by infection, tissue injury, or the production of inflammatory cytokines or after the contact of APCs with activated T cells. CD86 seems likely to play a more critical role in providing early and sustained costimulatory signals, whereas CD80-derived signals modulate the fate of the T cell response rather than its initiation. CTLA-4 is homologous to CD28 and binds CD80-CD86 with a much higher affinity than CD28. Consequently, CD28 competes with CTLA-4 to bind CD80 and CD86, resulting in enhanced T-cell responses by up-regulating cytokine secretion and inducing cell proliferation.

Learn more: cd80/cd86

This product is a Complement Serum freshly prepared from Human whole blood in cold and then frozen at -80°C to prevent degradation of complement activity. It can be used in the hemolytic plaque assays, complement fixation assays, and other lymphocytotoxicity and hemolytic procedures. This product is for research use only and is not intended for therapeutic or diagnostic applications. Learn more: Human Complement Serum Pooled

Anti-programmed cell death protein 1 (anti-PD-1) and anti-cytotoxic T-lymphocyte-associated protein 4 (anti-CTLA-4) monoclonal antibodies (mAbs) have revolutionized anticancer treatment. However, there are still many patients who do not respond or acquire resistance to these treatments. To overcome these limitations of therapeutic antibodies for immune checkpoints, Creative Biolabs offers immune checkpoint targeted small molecule drug development services to assist our customers with immune checkpoint research and drug development goals. Learn more: immune checkpoint molecule

In the stem cells therapy, the induced pluripotent stem cells (iPSCs) which are directly derived from patients' somatic cells reprogramming to an embryonic-like state. Since iPSCs could be coaxed into the desired cell types that would already be genetically matched with the patient, the immune rejection and the ethical issues can be potentially circumvented. Learn more: iPSC therapy

In humans, inhibitory NKRs are mainly encoded by genes in the leukocyte receptor complex (LRC), such as killer immunoglobulin-like receptors (KIRs), most of which interact with major histocompatibility complex (MHC) class I proteins. Activating NKRs are multichain complexes responsible for the induction of NK cell cytotoxicity, mainly including natural cytotoxicity receptors (NCRs, e.g., NKp30, NKp46, NKp44), DNAX accessory molecule 1 (DNAM1, CD226), natural killer group 2D (NKG2D, CD314), etc.

TIGIT (T cell immunoglobulin and ITIM domain), also known as VSig9, Vstm3, or WUCAM, is an inhibitory receptor member of the CD28 family. TIGIT binds to CD155 (PVR or Necl-5) with high affinity and weakly interacts with CD112 (PVRL2, nectin-2). TIGIT also competes with other counterparts, CD266 (DNAM-1) or CD96, to exert its immunosuppressive effects. Learn more: immune checkpoint TIGIT

Phosphatidic acid (PA) is the simplest natural glycerophospholipid in living organisms consisting of glycerol, an acyl chain, and a phosphate. As a minor component in biological membranes (about 1-4% of membrane lipids), PA is still involved in multiple intracellular processes. For example, PA is an intermediate for other phospholipids, acts as a lipid second messenger, and is also a modulator of physicochemical properties of the membrane. The related lipid lysophosphatidic acid (LPA) has only one acyl chain and carries a more negative charge than PA does when present in a phosphatidylcholine bilayer. Influenced by the ratio of the headgroup to the tail, PA is a cone-shaped lipid that tends to form monolayers spontaneously bulge towards the tail of hydrocarbons with an aqueous core surrounded by the hydrophilic headgroups. Whereas LPA is modeled as an inverted cone, which tends to form spherical micelles with headgroups surrounding the hydrophobic tails directed inward.

Next-generation sequencing, referred to simply as NGS, is a powerful tool for bacterial detection and microbial community analysis in a high-throughput manner. Creative Biolabs employs 16S rRNA metagenomic sequencing to support high-resolution and low-cost microbial community analysis services.

Learn more: 16s ribosomal rna gene sequencing